Search results for "Clinical medicine"

showing 10 items of 26067 documents

2019

Parthenolide (PT) is a sesquiterpene lactone isolated from Tanacetum parthenium. In this study, PT showed varying cytotoxic effects against different solid tumor cell lines. HCT116 (p53+/+) colon carcinoma cells and their parental HCT116 knockout p53 (p53-/-) cell lines showed a resistance degree of 2.36. On the other hand, wild-type U87.MG cells or cells transfected with a deletion-activated EGFR cDNA (U87.MGΔEGFR) exhibited slight sensitivity toward PT. Multidrug-resistant MDA-MB-231-BCRP cells were even more sensitive toward PT than sensitive MDA-MB-231-pcDNA cells with a resistance degree of 0.07 (collateral sensitivity). To the best of our knowledge, hypersensitivity (collateral sensit…

0301 basic medicinePharmacologyNF-κBIκB kinaseTransfection03 medical and health scienceschemistry.chemical_compoundIκBα030104 developmental biology0302 clinical medicinechemistryCell culture030220 oncology & carcinogenesisGene expressionCancer researchCytotoxic T cellPharmacology (medical)ParthenolideFrontiers in Pharmacology
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2021

Objective: Radical prostatectomy (RP) is a frequent treatment for men suffering from localized prostate cancer (PCa). Whilst offering a high chance for cure, it does not come without a significant impact on health-related quality of life. Herein we review the common adverse effects RP may have over the course of time.Methods: A collaborative narrative review was performed with the identification of the principal studies on the topic. The search was executed by a relevant term search on PubMed from 2010 to February 2021.Results: Rates of major complications in patients undergoing RP are generally low. The main adverse effects are erectile dysfunction varying from 11 to 87% and urinary incont…

medicine.medical_specialtyUrinary continencebusiness.industryProstatectomymedicine.medical_treatment030232 urology & nephrologyUrinary incontinencemedicine.disease03 medical and health sciencesProstate cancer0302 clinical medicineErectile dysfunctionQuality of life030220 oncology & carcinogenesismedicineSurgeryMajor complicationmedicine.symptomAdverse effectbusinessIntensive care medicineFrontiers in Surgery
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O Futuro da Saúde / Aptidão Física / Desempenho Esportivo

2017

O exercício relativo à saúde / aptidão física e desempenho esportivo tem mostrado um papel evolutivo ao longo do tempo. São apresentados fatores primários de grande escala, que provavelmente nos ajudarão a entender o caminho evolutivo futuro da saúde / aptidão física e desempenho esportivo. Esses fatores incluem: 1) a história do exercício, 2) o exercício em sua relação com a saúde, 3) a necessidade de aptidão física entre os militares e os socorristas, 4) a relação conflitante entre o esporte (representando o ápice da capacidade genômica humana para o exercício) versus a natureza excessivamente competitiva e compensada do esporte. Predominantemente, a necessidade de exercício como medicina…

medicine.medical_specialtyApplied psychologyGeneral Social Sciences030229 sport sciencesPeer review03 medical and health sciences0302 clinical medicineSocial integrationScale (social sciences)medicine030212 general & internal medicinePsychologyInclusion (education)General Environmental SciencePreventive healthcareFronteiras: Journal of Social, Technological and Environmental Science
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Les cancers du rein non à cellules claires : caractéristiques clinico-biologiques et prise en charge thérapeutique hors chirurgie

2020

Resume Les cancers du rein non a cellules claires representent pres de 25 % de l’ensemble des cancers du rein, et constituent un groupe de tumeurs tres heterogenes a la fois en termes de varietes histologiques, mais egalement d’anomalies biologiques oncogeniques. La presentation clinique ainsi que le pronostic des patients sont egalement tres variables. Compte tenu de la rarete de chaque entite tumorale, il n’existe que tres peu d’essais cliniques ayant porte sur une variete bien definie de cancer non a cellules claires. Ceci rend difficile l’interpretation de ces etudes, et donc l’emission de recommandations claires de prise en charge medicale pour la maladie avancee. Dans cet article, les…

0301 basic medicineGynecologyCancer Researchmedicine.medical_specialtybusiness.industryHematologyGeneral Medicine03 medical and health sciences030104 developmental biology0302 clinical medicineOncology030220 oncology & carcinogenesisMedicineRadiology Nuclear Medicine and imagingPapillary carcinomabusinessRenal carcinomaBulletin du Cancer
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L’échographie pulmonaire : une aide au diagnostic et au contrôle de la réponse à la kinésithérapie. À propos d’un cas

2017

Introduction L’echographie pulmonaire pourrait etre un outil interessant pour le kinesitherapeute puisqu’elle pourrait permettre d’ameliorer l’indication et le suivi du traitement par kinesitherapie respiratoire [1] . A notre connaissance, aucune etude n’a evalue l’impact de l’echographie pulmonaire sur le processus de decision clinique du kinesitherapeute. Ce rapport de cas aborde l’interet de l’echographie pulmonaire en kinesitherapie respiratoire chez une patiente avec une consolidation pulmonaire. Materiel, population et methode Ce rapport de cas est ecrit suivant les recommandations de « The CARE guideline » [2] . La patiente etait une femme de 68 ans, non intubee et hospitalisee dans …

03 medical and health sciences0302 clinical medicine030220 oncology & carcinogenesisRehabilitationPhysical Therapy Sports Therapy and Rehabilitation030212 general & internal medicineKinésithérapie, la Revue
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Taste Disturbance with Acetazolamide

1997

03 medical and health sciences0302 clinical medicinebusiness.industrymedicineMEDLINEPharmacology (medical)030204 cardiovascular system & hematologyAcetazolamidebusinessBioinformatics030226 pharmacology & pharmacymedicine.drugTaste disturbanceAnnals of Pharmacotherapy
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Imaging funzionale per diffusione (DWI) e ischemia cerebrale in fase acuta: Potenzialità diagnostiche e confronto con metodiche convenzionali

1997

Stroke is the third leading cause of death and is a major cause of long-term disability. Neuroprotective treatment within a 4-hour «therapeutic window» has proved highly efficacious in reducing morbility and mortality in animal model. It is with this background that the need for emergent diagnosis and therapy of acute stroke in strongly suggested. Computed tomography (CT) shows the parenchymal changes of acute stroke too late to be helpful, and its role has been primarily to evaluate the possibility of intracerebral or subarachnoid hemorrhage. While conventional magnetic resonance (MR) imaging can demonstrate parenchymal abnormalities 4–6 hours after ischemia, newer techniques such as diff…

medicine.medical_specialtySubarachnoid hemorrhageRadiological and Ultrasound Technologymedicine.diagnostic_testbusiness.industryIschemiaInfarctionMagnetic resonance imagingmedicine.diseaseNeuroprotection030218 nuclear medicine & medical imaging03 medical and health sciences0302 clinical medicineAnimal modelmedicineRadiology Nuclear Medicine and imagingcardiovascular diseasesNeurology (clinical)RadiologybusinessStroke030217 neurology & neurosurgeryCause of deathRivista di Neuroradiologia
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Un parcours de soins primaires pour améliorer la prise en charge et le pronostic des patients diabétiques avec une plaie de pied

2021

Resume Introduction Les plaies de pied diabetique (PPD) sont un probleme frequent, associe a un risque eleve d’amputation et de mortalite. L’adressage rapide a une structure specialisee du pied diabetique permet d’ameliorer le taux de cicatrisation et de diminuer le risque d’amputation. Une proportion importante de patients avec une PPD sont adresses tardivement vers ces structures specialisees. Un parcours de soins primaires des patients avec une PPD a ete developpe par l’International Diabetic Foot Care Group en collaboration avec le D-Foot International pour ameliorer l’orientation de ces patients vers les structures specialisees. Nous presentons une version adaptee au systeme de soin fr…

03 medical and health sciences0302 clinical medicineNutrition and DieteticsEndocrinology Diabetes and MetabolismInternal Medicine030209 endocrinology & metabolism030212 general & internal medicineCardiology and Cardiovascular MedicineMédecine des Maladies Métaboliques
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2019

Recent studies on extracellular RNA raised awareness that extracellular vesicles (EVs) isolated from cultured cells may co-purify RNAs derived from media supplements such as fetal bovine serum (FBS) confounding EV-associated RNA. Defined culture media supplemented with a range of nutrient components provide an alternative to FBS addition and allow EV-collection under full medium conditions avoiding starvation and cell stress during the collection period. However, the potential contribution of serum-free media supplements to EV-RNA contamination has remained elusive and has never been assessed. Here, we report that RNA isolated from EVs harvested from cells under serum-replacement conditions…

0301 basic medicineDifferential centrifugationHistologyChemistryRNACell BiologyMicrovesiclesReverse transcriptase03 medical and health sciencesChemically defined medium030104 developmental biology0302 clinical medicineBiochemistry030220 oncology & carcinogenesismicroRNAFetal bovine serumExtracellular RNAJournal of Extracellular Vesicles
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Students’ perceptions on three-way pedagogical models hybridization: contributing to the development of active identities

2021

The goal of the present study was to explore Primary Education students’ views on their involvement in a three pedagogical models’ hybridization (Health-Based Physical Education, Cooperative Learni...

Cooperative learningmedia_common.quotation_subject05 social sciencesPrimary education050301 educationPhysical Therapy Sports Therapy and Rehabilitation030229 sport sciencesEducationPhysical education03 medical and health sciences0302 clinical medicinePerceptionThree wayComputingMilieux_COMPUTERSANDEDUCATIONMathematics educationOrthopedics and Sports MedicinePsychology0503 educationmedia_commonSport, Education and Society
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